MimiCart : A new bi-compartmental implant
Cartilage defects often progress into osteoarthritis. Current treatments for defects are limited to specific age groups, lesion sites or sizes. The proposed solution offers a versatile solution, applicable to any defect size or location and eventually applicable even for the entire joint.
The solution is a bi-compartmental implant where the upper artificial cartilage involves a knitted spacer fabric filled with a hydrogel that has strong swelling potential and the lower part is a osteo-conductive porous knitted 3D fabric. The mechanical load-bearing function of the artificial cartilage originates from the restriction of the swelling by the spacer fabric fibers. The resulting swelling pressure is highly effective in load-bearing, and is the same mechanism employed by natural cartilage. The lower 3D fabric is treated to induce growth of bone into it, thus mechanically locking the implant in place.
By mixing cells in with a slowly degradable version of the hydrogel, an implant with regenerative capacity is obtained.
In the MimiCart project an implant for the clinical treatment of cartilage-bone defects will be developed. The targeted implant technology will be an off-the-shelf platform that can be implanted using minimally invasive arthroscopic techniques. Textile technologies will be combined with advanced hydrogels to mimic the internal biomechanical load-bearing mechanism of collagen fibers and proteogylcan ground substance in native cartilage. This will provide immediate pain free biomechanical function for the affected joint. The implant will also be enhanced with the patient’s own cartilage and progenitor cells that are intra-operatively collected and processed. This will allow natural cartilage to be regenerated as the implant resorbs, providing long-lasting healing of the defect.
Keita Ito, MD, Sc. D, Professor
Eindhoven University of Technology
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via RegMed XB Osteo-pharma; UMC Utrecht, HCM-medical, Fujijfilm, XPand, LTG, Utrecht University